Bgee: Gene Expression Evolution

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Expression data retrieved for the gene ENSMUSG00000025007: Aldh18a1 - in the anatomical structure: "aorta" at the stage: "infant" - Mus musculus

Query parameters Anatomical structure: aorta
Stage: infant
Gene: ENSMUSG00000025007 - Aldh18a1
Data parameters
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Affymetrix experiment E-MEXP-840

Experiment name Transcription profiling of aorta from mice underexpressing Fibulin-4 to investigate its role in elastic fibre assembly and cardio-vasuclar disease [E-MEXP-840]
Source ArrayExpress
Experiment description Extracellular elastic fibres apply structure and mechanical elasticity to organs such as large arteries, lungs and skin 1. Elastic fibres are assembled through polymerization of tropoelastin monomers and loss of elastin is associated with aneurysmal degeneration of the aorta 2. The Fibulins are a six-member protein family hypothesized to function as intermolecular bridges that stabilize the organization of extracellular matrix structures such as elastic fibres and basement membranes 3. Fibulin-4 is found in the medial layers of arteries and moderately expressed in heart valves 4. To examine a potential role of Fibulin-4 in elastic fibre assembly and cardio-vascular disease we generated a mouse model underexpressing Fibulin-4. To get insight into the underlying molecular pathways involved in aneurysm formation, we determined the aorta transcriptome of Fibulin-4R/R animals and identified biological processes that were significantly overrepresented including apoptosis and cell death as well as several novel gene targets implicated in the response to aortic failure. We conclude that decreased Fibulin-4 expression causes aberrant composition of the elastin layers in the aorta and valvular leaflets, resulting in aortic aneurysms and heart abnormalities.
Chips
  • Chip ID: WM2 - Annotation by Bgee curators: Anatomical structure ID: MA:0000062 - Developmental stage ID: MmusDO:0000038
    • Probeset ID: 1415836_at - Mapped to gene: ENSMUSG00000025007 - Detection flag: present - Quality: high quality
    • Probeset ID: 1435855_x_at - Mapped to gene: ENSMUSG00000025007 - Detection flag: present - Quality: high quality
    • Probeset ID: 1437325_x_at - Mapped to gene: ENSMUSG00000025007 - Detection flag: present - Quality: high quality
    • Probeset ID: 1437620_x_at - Mapped to gene: ENSMUSG00000025007 - Detection flag: marginal - Quality: low quality
  • Chip ID: WM4 - Annotation by Bgee curators: Anatomical structure ID: MA:0000062 - Developmental stage ID: MmusDO:0000038
    • Probeset ID: 1415836_at - Mapped to gene: ENSMUSG00000025007 - Detection flag: present - Quality: high quality
    • Probeset ID: 1435855_x_at - Mapped to gene: ENSMUSG00000025007 - Detection flag: present - Quality: high quality
    • Probeset ID: 1437325_x_at - Mapped to gene: ENSMUSG00000025007 - Detection flag: present - Quality: high quality
    • Probeset ID: 1437620_x_at - Mapped to gene: ENSMUSG00000025007 - Detection flag: marginal - Quality: low quality
  • Chip ID: WM3 - Annotation by Bgee curators: Anatomical structure ID: MA:0000062 - Developmental stage ID: MmusDO:0000038
    • Probeset ID: 1415836_at - Mapped to gene: ENSMUSG00000025007 - Detection flag: present - Quality: high quality
    • Probeset ID: 1435855_x_at - Mapped to gene: ENSMUSG00000025007 - Detection flag: present - Quality: high quality
    • Probeset ID: 1437325_x_at - Mapped to gene: ENSMUSG00000025007 - Detection flag: present - Quality: high quality
    • Probeset ID: 1437620_x_at - Mapped to gene: ENSMUSG00000025007 - Detection flag: marginal - Quality: low quality
  • Chip ID: WM1 - Annotation by Bgee curators: Anatomical structure ID: MA:0000062 - Developmental stage ID: MmusDO:0000038
    • Probeset ID: 1415836_at - Mapped to gene: ENSMUSG00000025007 - Detection flag: present - Quality: high quality
    • Probeset ID: 1435855_x_at - Mapped to gene: ENSMUSG00000025007 - Detection flag: present - Quality: high quality
    • Probeset ID: 1437325_x_at - Mapped to gene: ENSMUSG00000025007 - Detection flag: present - Quality: high quality
    • Probeset ID: 1437620_x_at - Mapped to gene: ENSMUSG00000025007 - Detection flag: marginal - Quality: low quality

Affymetrix experiment GSE16012

Experiment name Transcription profiling of mouse Elastin (Eln+/-) aorta and aortic valve tissue [GSE16012]
Source GEO
Experiment description Elastin wild type Eln+/+ and Eln+/- mouse aorta and aortic valve tissue. In the study, we demonstrated differential gene expression in juvenile elastin deficient mouse valve tissue. Experiment Overall Design: In the study, we hybridized RNA from Elastin wild type (Eln+/+) aorta tissue, elastin wild type (Eln+/+) aortic valve tissue, elastin (Eln+/-) aorta tissue and elastin (Eln+/-) aortic valve tissue to Affymetrix GeneChip Mouse Genome 430 2.0 Array
Chips
  • Chip ID: GSM400643 - Annotation by Bgee curators: Anatomical structure ID: MA:0000062 - Developmental stage ID: MmusDO:0000038
    • Probeset ID: 1415836_at - Mapped to gene: ENSMUSG00000025007 - Detection flag: present - Quality: high quality
    • Probeset ID: 1435855_x_at - Mapped to gene: ENSMUSG00000025007 - Detection flag: present - Quality: high quality
    • Probeset ID: 1437325_x_at - Mapped to gene: ENSMUSG00000025007 - Detection flag: present - Quality: high quality
    • Probeset ID: 1437620_x_at - Mapped to gene: ENSMUSG00000025007 - Detection flag: marginal - Quality: low quality
  • Chip ID: GSM400641 - Annotation by Bgee curators: Anatomical structure ID: MA:0000062 - Developmental stage ID: MmusDO:0000038
    • Probeset ID: 1415836_at - Mapped to gene: ENSMUSG00000025007 - Detection flag: present - Quality: high quality
    • Probeset ID: 1435855_x_at - Mapped to gene: ENSMUSG00000025007 - Detection flag: present - Quality: high quality
    • Probeset ID: 1437325_x_at - Mapped to gene: ENSMUSG00000025007 - Detection flag: present - Quality: high quality
    • Probeset ID: 1437620_x_at - Mapped to gene: ENSMUSG00000025007 - Detection flag: marginal - Quality: low quality
  • Chip ID: GSM400642 - Annotation by Bgee curators: Anatomical structure ID: MA:0000062 - Developmental stage ID: MmusDO:0000038
    • Probeset ID: 1415836_at - Mapped to gene: ENSMUSG00000025007 - Detection flag: present - Quality: high quality
    • Probeset ID: 1435855_x_at - Mapped to gene: ENSMUSG00000025007 - Detection flag: present - Quality: high quality
    • Probeset ID: 1437325_x_at - Mapped to gene: ENSMUSG00000025007 - Detection flag: present - Quality: high quality
    • Probeset ID: 1437620_x_at - Mapped to gene: ENSMUSG00000025007 - Detection flag: marginal - Quality: low quality
  • Chip ID: GSM400645 - Annotation by Bgee curators: Anatomical structure ID: MA:0000062 - Developmental stage ID: MmusDO:0000038
    • Probeset ID: 1415836_at - Mapped to gene: ENSMUSG00000025007 - Detection flag: present - Quality: high quality
    • Probeset ID: 1435855_x_at - Mapped to gene: ENSMUSG00000025007 - Detection flag: present - Quality: high quality
    • Probeset ID: 1437325_x_at - Mapped to gene: ENSMUSG00000025007 - Detection flag: present - Quality: high quality
    • Probeset ID: 1437620_x_at - Mapped to gene: ENSMUSG00000025007 - Detection flag: marginal - Quality: low quality