Bgee: Gene Expression Evolution

Expression data retrieved for the gene ENSG00000196535: MYO18A - in the anatomical structure: "Anatomical System" at the stage: "Human developmental stage" - Homo sapiens

Query parameters Anatomical structure: Anatomical System
Stage: Human developmental stage
Gene: ENSG00000196535 - MYO18A
Data parameters
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Hide | TopRNA-Seq

RNA-Seq experiment GSE30352

Experiment name The evolution of gene expression levels in mammalian organs [GSE30352]
Source GEO
Experiment description Changes in gene expression are thought to underlie many of the phenotypic differences between species. However, large-scale analyses of gene expression evolution were until recently prevented by technological limitations. Here we report the sequencing of polyadenylated RNA from six organs across ten species that represent all major mammalian lineages (placentals, marsupials and monotremes) and birds (the evolutionary outgroup), with the goal of understanding the dynamics of mammalian transcriptome evolution. We show that the rate of gene expression evolution varies among organs, lineages and chromosomes, owing to differences in selective pressures: transcriptome change was slow in nervous tissues and rapid in testes, slower in rodents than in apes and monotremes, and rapid for the X chromosome right after its formation. Although gene expression evolution in mammals was strongly shaped by purifying selection, we identify numerous potentially selectively driven expression switches, which occurred at different rates across lineages and tissues and which probably contributed to the specific organ biology of various mammals. Our transcriptome data provide a valuable resource for functional and evolutionary analyses of mammalian genomes.
Samples
  • Sample ID: GSM752691 - log2 RPK threshold: -1.772 - Annotation by Bgee curators: Anatomical structure ID: EV:0100167 - Developmental stage ID: HsapDO:0000136
    • Gene ID: ENSG00000196535 - log2 RPK score: 5.682 - Detection flag: present - Quality: high quality
  • Sample ID: GSM752692 - log2 RPK threshold: -3.019 - Annotation by Bgee curators: Anatomical structure ID: EV:0100167 - Developmental stage ID: HsapDO:0000157
    • Gene ID: ENSG00000196535 - log2 RPK score: 4.883 - Detection flag: present - Quality: high quality
  • Sample ID: GSM752694 - log2 RPK threshold: -1.643 - Annotation by Bgee curators: Anatomical structure ID: EV:0100167 - Developmental stage ID: HsapDO:0000142
    • Gene ID: ENSG00000196535 - log2 RPK score: 4.342 - Detection flag: present - Quality: high quality
  • Sample ID: GSM752696 - log2 RPK threshold: -6.598 - Annotation by Bgee curators: Anatomical structure ID: EV:0100169 - Developmental stage ID: HsapDO:0000118
    • Gene ID: ENSG00000196535 - log2 RPK score: 2.774 - Detection flag: present - Quality: high quality
  • Sample ID: GSM752697 - log2 RPK threshold: -0.725 - Annotation by Bgee curators: Anatomical structure ID: EV:0100293 - Developmental stage ID: HsapDO:0000095
    • Gene ID: ENSG00000196535 - log2 RPK score: 5.334 - Detection flag: present - Quality: high quality
  • Sample ID: GSM752698 - log2 RPK threshold: -0.843 - Annotation by Bgee curators: Anatomical structure ID: EV:0100293 - Developmental stage ID: HsapDO:0000162
    • Gene ID: ENSG00000196535 - log2 RPK score: 6.097 - Detection flag: present - Quality: high quality
  • Sample ID: GSM752699 - log2 RPK threshold: -2.516 - Annotation by Bgee curators: Anatomical structure ID: EV:0100018 - Developmental stage ID: HsapDO:0000151
    • Gene ID: ENSG00000196535 - log2 RPK score: 5.059 - Detection flag: present - Quality: high quality
  • Sample ID: GSM752700 - log2 RPK threshold: -2.465 - Annotation by Bgee curators: Anatomical structure ID: EV:0100018 - Developmental stage ID: HsapDO:0000123
    • Gene ID: ENSG00000196535 - log2 RPK score: 5.974 - Detection flag: present - Quality: high quality
  • Sample ID: GSM752701 - log2 RPK threshold: -2.928 - Annotation by Bgee curators: Anatomical structure ID: EV:0100018 - Developmental stage ID: HsapDO:0000167
    • Gene ID: ENSG00000196535 - log2 RPK score: 4.304 - Detection flag: present - Quality: high quality
  • Sample ID: GSM752702 - log2 RPK threshold: -2.495 - Annotation by Bgee curators: Anatomical structure ID: EV:0100096 - Developmental stage ID: HsapDO:0000160
    • Gene ID: ENSG00000196535 - log2 RPK score: 4.188 - Detection flag: present - Quality: high quality
  • Sample ID: GSM752703 - log2 RPK threshold: -2.226 - Annotation by Bgee curators: Anatomical structure ID: EV:0100096 - Developmental stage ID: HsapDO:0000120
    • Gene ID: ENSG00000196535 - log2 RPK score: 3.485 - Detection flag: present - Quality: high quality
  • Sample ID: GSM752704 - log2 RPK threshold: -2.187 - Annotation by Bgee curators: Anatomical structure ID: EV:0100096 - Developmental stage ID: HsapDO:0000161
    • Gene ID: ENSG00000196535 - log2 RPK score: 3.759 - Detection flag: present - Quality: high quality
  • Sample ID: GSM752705 - log2 RPK threshold: -2.174 - Annotation by Bgee curators: Anatomical structure ID: EV:0100089 - Developmental stage ID: HsapDO:0000158
    • Gene ID: ENSG00000196535 - log2 RPK score: 4.28 - Detection flag: present - Quality: high quality
  • Sample ID: GSM752706 - log2 RPK threshold: -2.195 - Annotation by Bgee curators: Anatomical structure ID: EV:0100089 - Developmental stage ID: HsapDO:0000116
    • Gene ID: ENSG00000196535 - log2 RPK score: 4.688 - Detection flag: present - Quality: high quality
  • Sample ID: GSM752707 - log2 RPK threshold: -4.615 - Annotation by Bgee curators: Anatomical structure ID: EV:0100102 - Developmental stage ID: HsapDO:0000121
    • Gene ID: ENSG00000196535 - log2 RPK score: 2.521 - Detection flag: present - Quality: high quality
  • Sample ID: GSM752708 - log2 RPK threshold: -1.469 - Annotation by Bgee curators: Anatomical structure ID: EV:0100102 - Developmental stage ID: HsapDO:0000095
    • Gene ID: ENSG00000196535 - log2 RPK score: 4.733 - Detection flag: present - Quality: high quality